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No patient is quite like the horse

The lead candidate 37 (HFI-419) exhibits brain exposure following intravenous administration in rats but was found to be rapidly degraded to the corresponding deacetylated and less active IRAP inhibitor (Mountford et al., 2014)

This work was financially supported, in part, by a research grant to MG from Sigma Tau Italy, which is the manufacturer of several carnitines including L-carnitine and acetyl-L-carnitine that were utilized in the study

Research indicates that this peptide modulates angiogenesis through upregulation of vascular endothelial growth factor (VEGF) expression and enhancement of endothelial cell proliferation and migration